A good idea is to make a backup copy of your UI files once you get it re-configured how you like it. This way whatever reset / crashes, etc happen, you don't have to spend all that time putting all your windows back where you want them and re-typing macros, etc.
There are 2 files you need and want to save someplace safe. They are located in your new 2.5 directory. I've used <NAME> to be generic, there are no <>'s, just the character's name.
<NAME>_SOD25
UI_<NAME>_SOD25
The first one contains your a few things including Abilities, HotButtons and Socials (ie Macros).
The second one contains the data for the physical layout of your UI ... window positions, etc.
(I placed this post in this thread because I wasn't able to create a new thread in this forum).