NewScientist.com: Cheap, safe drug kills most cancers

Armando

Dalayan Beginner
It sounds almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their “immortality”. The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe.

that sounds good...

It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.

that sounds even better!

the article goes on to explain a cancer cells "immortality" and how DCA counters it

When cells switch mitochondria off, they become “immortal”, outliving other cells in the tumour and so becoming dominant. Once reawakened by DCA, mitochondria reactivate apoptosis and order the abnormal cells to die.

hot diggity.

The next step is to run clinical trials of DCA in people with cancer. These may have to be funded by charities, universities and governments: pharmaceutical companies are unlikely to pay because they can’t make money on unpatented medicines.

:psyduck:

well i'm sure that an effective drug will still soon enter the market at an affordable price (to save lives!), even if there is no money to be made.

free market = key to innovation.

http://www.newscientist.com/article/dn10971?DCMP=NLC-nletter&nsref=dn10971
 
Sadly Tryfaen may well be right.

Id post more on the matter but I need to go set up a web site and service to ship the miracle drug to US citizens from here in Canada.
 
Possibly would be allowed simply because they would lose more $ not allowing it to other countries that do...but omg did someone say parasite eve?
 
Yeah, it does sound too good to be true. And like my pappy always said, if it sounds too good to be true, it probably is.

But, putting that aside for the moment . .

DCA has been tested in patients and has been shown to cause toxic neuropathy. linkey here This is what was referred to in the op article, if you read it all the way through, near the end: "DCA can cause pain, numbness and gait disturbances in some patients, but this may be a price worth paying if it turns out to be effective against all cancers. " While the dosage at which DCA causes toxic neuropathy may be quite high compared to the dosage at which it normalizes some forms of cancer cells (quoted in the linked article at 25 mg/kg/day, which is quite high), it's something that will have to be watched carefully.

In addition, although there's good cause for further research, there's little chance it could cure "all cancers" since cancers vary significantly between tissue affected, and even then there can be many different cancer types for the same tissue. Also, the study published only demonstrated tumor reduction, not elimination. This might be a treatment that would work well in combination with other treatments, or it might be a good treatment to extend lifetime and quality of life in a terminal case.

Finally, there's no reason that pharmaceutical companies would not get involved if there were a good chance that it would really do what it says it will. Pharmaceutical companies have many ways of patenting their drug: whether that be patenting the exact "formula" in the pill they feed you, or patenting the delivery system used. In addition, the molecule may be modified slightly to form a molecule that IS patentable: for instance, remove one of the chlorines and replace it with fluorine. In fact, doing so may increase the efficacy of the molecule. Regardless, there's lots of research to be done before DCA could be a viable treatment for any cancer type.
 
guys the cure for cancer is going to be nanorobots that home in on cancer cells through genetically altering bacteria to give off signals then the nano robots are going to heat up and destroy the cancer cells from the inside

this will cost alot of money and never be practical, but will cure cancer, and is going to come out in 10-15 years
 
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