if he is DE or iksar and went COI for heartlands and Good for diety, basically Jayla. He could probably manage it without much problem.
If he isn't either, he will have to grind faction with grobb guards and do at least part of the gate quest from grobb blackscales, ( no evil or blackscale faction hit ) for spells first.
Lawful good will probably work as well, as long as he doesn't commit to silver crown until after 55. But with the same provisos as noted above, and the additional one that once he starts grinding silver crown he will become kos to blackscales in grobb, who reside in only a small-you-will never-go-there-again at 55 section.
But I'm not sure thats what he is asking. Because at end game, the only thing that matters is having a 20% bonus, which you can do with any choice. But a polar choice like Lawful good, lawful evil and chaotic either is going to be easier then neutral anything. Neutral being for those that want a balancing mini game with their deity choice.
But if he isn't DE and Iksar and is new to the game, dishing cult of entropy early on sucks. But there isn't really any choice thats bad long run if you are willing to work through the hurdles. As the only bad choice is one that doesn't allow you to get max diety.
That said I should mention most necs go marlow or gradalsh, since the former doesn't break your sewer faction and only pisses off blackscale in grobb. Gradalsh being fine everywhere.
But if he really wants to be Good and end game, he should ditch the necro and make a mage. Do 40%+ more dps, have better mana regen and not care about whether some quest adds or deletes .0003% more dps, because he can always baw in Classes for 5% more dps anytime he wants and get it.